HEAD
Marija Glavas Dodov, PhD, Professor
Specialist in pharmaceutical technology
Tel. (++389) 2 3126 032; ext. 115
Fax. (++ 389) 2 312 3054
E-mail: magl@ff.ukim.edu.mk
ADDRESS
Majka Tereza 47,
PO Box 36,
1000 Skopje, R. Macedonia
HUMAN RESOURCES
- Maja Simonoska Crcarevska, PhD, Associate Professor
- Katerina Gorachinova, PhD, Full Professor
- Marija Glavas Dodov, PhD, Full Professor
- Kristina Mladenovska, PhD, Full Professor
- Renata Slavevska Raicki, PhD, Full Professor
- Nikola Geshkovski, PhD, Assistant Professor
- Blagorodna Koprivica, M.Sc. Laboratory Bioengineer
ABOUTH THE CENTER
The Center for Pharmaceutical Nanotechnology (CPN) was established in 2008 as a Center for micro/nanotechnology and design of micro/nanosystems for targeted drug delivery, and in 2009, has been renamed to the Center for Pharmaceutical Nanotechnology. Since its commencement, the CPN exists as a separate unit within the Faculty. First head of the Center was Prof. Katerina Gorachinova (12.12.2008-01.12.2009). Prof. Marija Glavas Dodov was Head of the Center from 01.12.2009 to 01.04.2014. From 2014 till today, this position is held by Assoc. Prof. Maja Simonoska Crcarevska.
CAPACITIES
The Center for Pharmaceutical Nanotechnology has the following equipment:
- Spray-dryer (Buchi Mini Spray dryer B-290, Switzerland);
- Zetasizer Nano Series, Nano-ZS, Malvern Instruments Ltd., UK
- Particle Size Analyzer (Mastersizer 2000, Malvern Instr., Ltd, UK) equipped with cells:
- Scirocco 2000, Malvern Instr., Ltd, UK, (measurement for dry powder);
- Hydro 2000S, Malvern Instr., Ltd, UK, (measurement of dispersions);
- Shaking water bath with thermostat (Unitronic OR, Selecta, Barcelona, Spain);
- Magnetic stirrer (Variomag, Multipoint HP 15, Germany);
- Magnetic hotplate stirrer (Jenway, UK);
- Ultrasonic water bath (Ultrawave Limited, Cardif, UK);
- HPLC system (Agilent 1200 Series, DAD detector, Germany);
- Freeze Dryer (Labconco, FreeZone5L Feeze Dry System, USA);
- Homogenizer (IKA T25 basic, Germany);
- Autoclave (Melag Avtoklav 23, Germany);
- UV-VIS Spectrophotometers;
- ERWEKA dissolution system;
- ERWEKA apparatus for disintegration;
- Aseptic chambers;
- Chambers for stability studies (Kottermann, Germany).
ACTIVITIES
The main activity of the Center for Pharmaceutical Nanotechnology (CPN) is providing services and analyzes in the field of pharmaceutical technology, micro/nanotechnology, biopharmacy and cosmetology; giving expert opinions and consulting services, as well as preparation of expert reports, methodological procedures and laboratory analyzes.
Within the CPN, the following activities are performed:
- Scientific and research activity: fundamental and applied research in the field of Pharmaceutical technology, Biopharmacy, Cosmetology and Micro/Nanotechnology: design, development, characterization and evaluation of conventional pharmaceutical dosage forms, dosage forms with modified release, micro/nanosystems foe targeted and controlled release of active substances, cosmetic raw materials and products, nutriceuticals, stability studies for active substances and products, etc.Educational activity: training of staff and students on the principle of education based on science and scientific research, dissemination of knowledge, experiences and skills, publication and popularization of the research.
- Applicative activity: development and performance of analyzes, expertise, provision of professional laboratory and consulting services aimed at various aspects of dosage forms in the frame of technical capabilities and professional competence.
OFFERED ANALYSES AND SERVICES
The following analyzes and services are performed within the CPN:
- Design, development and formulation of conventional dosage forms, as well as dosage forms with modified release, micro/nanosystems, cosmetic products, nutriceuticals;
- Preparation and optimization of the above listed systems;
- Physico-chemical characterization of systems;
- Pharmaceutical-technological characterization of systems and stability testing for active substances and products;
- Biopharmaceutical characterization – biodistribution, efficiency, biocompatibility and biosafety, in-vitro/in-vivo correlation;
- Professional/Expert opinions in the area of preformulation, formulation and production of different dosage forms and products.
All offered analysis and services are performed in accordance with national and international quality standards.
| 1. | Formulation (formulation might encompass multiple phases and implementation of different pharmaceutical-technological procedures and physico-chemical analyzes) | Contract price (depends from complexity of procedures) |
| 2. | Preparation and optimization (after preparation of formulation according to selected method, during optimization, development, standardization and validation of procedures for characterization follows. These procedures are specific and unique for each formulation in the phase of development.) | Contract price (depends from complexity of procedures) |
| 3. | Physico-chemical characterization (procedures and methods are specific for each formulation in the phase of development and they will be developed, standardized and validated during research project) | Contract price (depends from complexity of procedures)) |
| 4. | Pharmaceutical-technological characterization and stability studies | Contract price (depends from complexity of procedures) |
| 5. | Biopharmaceutical characterization – Biodistribution studies | Contract price (depends from complexity of procedures) |
| 6. | Biopharmaceutical characterization – Efficacy studies | Contract price (depends from complexity of procedures) |
| 7. | Biopharmaceutical characterization – Biocompatibility and toxicity studies | Contract price (depends from complexity of procedures) |
| 8. | Biopharmaceutical characterization – In vitro/ in vivo correlation | Contract price (depends from complexity of procedures) |
| 9. | Professional opinions related to preformulation, formulation and manufacturing of pharmaceutical dosage forms | 500 EUR |
| 10. | Expert opinions related to preformulation, formulation and manufacturing of pharmaceutical dosage forms | 500 EUR |
| 11. | Measurement of particle size and particle size distribution by laser difractometry (dry powder, aqueous dispersion) according to manufacturer method | 200 EUR per series |
| 12. | Measurement of particle size and particle size distribution by photon correlation spectroscopy according to manufacturer method | 200 EUR per series |
| 13. | Measurement of particle size and particle size distribution by laser difractometry (non- aqueous dispersion) according to manufacturer method | 300 EUR per series |
| 14. | Development and validation of method for measurement of particle size and particle size distribution by laser difractometry (dry powder, aqueous dispersion) | 1.000 EUR (up to 3 series) |
| 15. | Development and validation of method for measurement of particle size and particle size distribution by photon correlation spectroscopy | 1.000 EUR (up to 3 series) |
| 16. | Development and validation of method for measurement of particle size and particle size distribution by laser difractometry (non- aqueous dispersion) | 1.500 EUR (up to 3 series) |
| 17. | Measurement of particle size and particle size distribution by optical microscopy according to manufacturer method | 150 EUR per series |
| 18. | Development and validation of method for measurement of particle size and particle size distribution by optical microscopy | 750 EUR (up to 3 series) |
| 19. | Measurement of zeta potential by photon correlation spectroscopy according to manufacturer method | 200 EUR per series |
| 20. | Development and validation of method for measurement of zeta potential by photon correlation spectroscopy | 1.000 EUR (up to 3 series)) |
| 21. | Expert/ professional opinion for categorization and effects of cosmetic raw materials | 250 EUR per raw material |
| 22. | Expert/ professional opinion for categorization and effects of cosmetic product | 500 EUR per product |
| 23. | Consulting services for development and design of pharmaceutical dosage form | Contract price (depends from complexity of procedures) |
| 24. | Development of cosmetic products | Contract price (depends from complexity of procedures) |
| 25. | Consulting services for development and design of cosmetic products | Contract price (depends from complexity of procedures) |
| 26. | Stability studies of cosmetic products | Contract price (depends from complexity of procedures) |
| 27. | Studies for efficacy and safety of cosmetic products | Contract price (depends from complexity of procedures) |
*In certain cases price might be higher